Endocrine Abstracts

Monogenic obesity disorders and mouse models of obesity have overwhelmingly pointed to hyperphagia as the predominant genetic force in promoting obesity, it was therefore no surprise when the most robust common variant associated with obesity from GWAS studies was associated with increased energy intake. We and other groups have shown that variants in the FTO gene are not associated with increased food intake per se, but rather display a preference for energy dense foods resul...

Introduction: Psychiatric disturbance is a recognised complication of glucocorticoid therapy. Patients on a daily dose of 40 mg of prednisolone or its equivalent are at risk of developing steroid psychosis. Psychotic reactions with replacement doses of glucocorticoid are uncommon. We describe a patient with newly diagnosed hypopituitarism who developed severe steroid induced psychosis with low dose hydrocortisone.Case report: A 72-year-old lady presented...